OBJECTIVES: To assess health utilities and examine factors affecting health utilities among patients with moderate to severe psoriasis in China. METHODS: Data were obtained from a cross-sectional HRQoL survey of psoriasis patients in 29 tertiary hospitals of 7 cities in China from June to July, 2012. Eligible patients were assessed with moderate to severe psoriasis by physicians and treated with prescriptions during the visit/hospitalization. Degree of moderate and severe was estimated by physicians based on definition of BSA score 3-10% and >10%. Participants completed HRQoL measures of EuroQol 5 domains (EQ-5D), Short Form 6 domains (SF-6D) and Dermatology Life Quality Index (DLQI). Socio-demographic and treatment satisfaction information were also collected from the participants. Mean scores were compared and stepwise multivariate linear regression was conducted to assess factors associated with health utilities. RESULTS: A total of 150 patients were included with 50% female, mean age of 43.87 years and mean disease duration of 5.19 years. About 22.67% patients reported having at least one comorbidity with anxiety/depression (14.00%) and related infection (10.00%) listed on the top. 36.67% patients expressed dissatisfaction with their current treatment. Mean EQ-5D, EQ-VAS, SF-6D and DLQI scores were 0.64, 63.23, 0.72 and 11.09, respectively, with significant difference between the severe and moderate group in all measures(0.50 vs. 0.77, 58.12 vs. 67.48, 0.67 vs.0.75, 14.43 vs. 8.33, all p<0.001). Regression analysis indicated that health severity indicated by DLQI score was significantly associated with value scores of EQ-5D, EQ-VAS, SF-6D. Sleeplessness and living in Tier 1st city decreased EQ-5D and SF-6D scores and treatment dissatisfaction had the negative impact on EQ-VAS and SF-6D scores with statistic significant.  CONCLUSIONS: Compared with moderate patients, patients with severe psoriasis have poorer health utilities. Increasing the patients’ satisfaction with their treatment and controlling insomnia may raise their health utilities effectively.