Medication errors is a major issue that every health care setting keeps addressing because it has a direct bearing on the safety of the patients. The results across the globe have demonstrated that the drug interactions continue to be a leading cause of errors. OBJECTIVES: The stduy was carried out with the obejctive of detecting the medication errors in the inpatients and profile them. METHODS: This study was carried out in an inpatient setting of a private tertiary care hospital. Medication errors were identified from patients' files, using Micromedex on PDA.  17 errors were fixed as the becnmark and assessments were done using this. RESULTS: The results are based on data obtained from 1225 patients [709 male, 516 female]. The average age of the patients was found to be 56.8±0.5 years. The average number of medications prescribed was 10.6±0.2. 585 patients were found to be aged 60 years or more and 613 patients were in the age group 18-60 years. Out of the 1225 patients, 848 did not have any medication error. An error was noted on only in 377 patient profiles. The total number of medication errors was found to be 638. Of these, 597 were errors ‘with no harm’ and only 41 were errors ‘with harm’. Of these medication errors, drug interactions (DIs) were found to be leading the list with 50% of the medication errors. Cardiovascular agents contributed maximum to the DIs followed by anticoagulants and antimicrobial agents. Only 172 DIs had a moderate severity. DIs was followed by duplication of therapy (20%), incorrect interval (10%), monitoring error, incompleteness of prescription, omission error and overdosing, respectively. CONCLUSIONS: These results confirm that drug interaction continue to lead the list of medication errors in Indian tertiary health care settings. The study is ongoing to determine the interventions to reduce the errors.