OBJECTIVES: Osteoarthritis is characterized by joint pain and mobility impairment associated with the gradual wearing of cartilage. Osteoarthritis poses a substantial and increasing burden on society as a result of impaired health-related quality of life and the socio-economic impact. In Russia, there are no solid estimates of the magnitude of the condition. This study is aimed to assess co-morbidity, quality of life (QOL), work/productivity loss, and medical resource utilization in Russian urban adults with osteoarthritis. METHODS: Patients’ self-reported data were collected from 2011 National Health and Wellness Survey (NHWS). Survey samples represented major urban areas in Russia. QOL was measured by the physical component score (PCS) and mental component score (MCS) of the Short Form-12 (SF-12). Loss of work productivity was measured by the Work Productivity and Activity Impairment instrument. Medical resource utilization was measured by healthcare provider, ambulance request and hospitalization in the past 6 months. RESULTS: Of the 10,039 adult respondents, 733 (7.3%) were diagnosed with osteoporosis (2.2% not diagnosed with osteoarthritis and 88.1% have not experienced arthritis at all). Average age of patients diagnosed with osteoarthritis was 54.1 years. Diagnosed osteoarthritis group reported more co-morbidities (sleep difficulties 51%, high blood pressure 46%, pain 44%, insomnia 37%, arrhythmia 30%, high cholesterol 21%), lower mean scores of PCS (40.4 vs.47.3) and similar MCS (43.3 vs.43.8). More patients visited healthcare providers (83% vs.70%), and a higher percentage were hospitalized (17% vs. 9%) over the past 6 months compared to those not experiencing arthritis. Furthermore, osteoarthritis group reported 37.6% impairment in daily activity compared to 25.3% of those not experiencing arthritis. All mentioned differences were statistically significant (p<0.05). CONCLUSIONS: From Russian NHWS results, patients diagnosed with osteoarthritis suffer from impairment in QOL, work/productivity loss and more co-morbidities. Findings indicate there is still an unmet medical need in Russian osteoarthritis patients.