OBJECTIVES: Although hypercholesterolemia (high levels of cholesterol in the blood) itself is asymptomatic, longstanding elevation of serum cholesterol can lead to increase the risk of cardiovascular disease, particularly coronary heart disease. In Russia, there are no solid estimates of the magnitude of this condition. This study is aimed to assess co-morbidity, quality of life (QoL), work productivity loss, activity impairment, and medical resource utilization in Russian urban adults with hypercholesterolemia. METHODS: Patients’ self-reported data were collected from 2011 National Health and Wellness Survey (NHWS). Survey sample represented major urban areas in Russia. QoL was measured by the physical component summary (PCS) and mental component summary (MCS) scores of the SF-12v2 . Work productivity loss and activity impairment were measured by the validated Work Productivity and Activity Impairment (WPAI) questionnaire. Medical resource utilization was measured by healthcare provider visits, emergency room visits, and hospitalizations in the past 6 months. RESULTS: Of the 10,039 adult respondents, 802 (7.98%) were experiencing hypercholesterolemia, of which 89% self-reported physician diagnosis, and only 60% were currently using some sort of medication. Average age of patients diagnosed with high cholesterol was 53.2 years. Compared to those not experiencing hypercholesterolemia, the diagnosed group reported more comorbidities (headache 66%, hypertension 54%, sleep difficulties 54%, insomnia 44%, pain 41%, heartburn 40%), lower mean PCS (40.7 vs. 47.1), and similar MCS (41.8 vs. 43.8). More patients visited healthcare providers (88% vs. 70%) and a higher percentage were hospitalized (14% vs. 9%) over the past 6 months. Furthermore, hypercholesterolemia patients reported 34.2% impairment in daily activities compared to 25.0% in the not experiencing hypercholesterolemia group. All mentioned differences were statistically significant (p<0.05). CONCLUSIONS: From Russian NHWS results, patients experiencing hypercholesterolemia suffer from lower QOL, work productivity loss, and more comorbidities. Findings indicate there is still an unmet medical need in Russian hypercholesterolemia patients.