OBJECTIVES: Atopic dermatitis (AD) is a common chronic skin condition in childhood that has negative impact on both patients and their families. A survey was conducted to evaluate the disease burden, quality of life (QOL) and financial impact of moderate to severe pediatric AD in the Asia Pacific region. This analysis focuses on the QOL impact of pediatric AD. METHODS: A cross sectional online survey was conducted among 1028 parents of children with moderate to severe AD in 12 countries: Australia, China, Hong Kong, India, Indonesia, Korea, Malaysia, Philippines, Singapore, Taiwan, Thailand and Vietnam. The Infant’s Dermatitis Quality of Life Index (IDQOL) was used for children less than 4 years old and the Children’s Dermatology Life Quality Index (CDLQI) for those aged between 4 to 16 years. The Dermatitis Family Impact (DFI) was used to assess the impact on family life. The maximum score for all three questionnaires is 30, categorized into 5 effect groups; none (0-1), small (2-6), moderate (7-12), very large (13-18) and extremely large effects (19-30). Severity of disease was measured using the Nottingham Eczema Severity scores (NESS). RESULTS: The average QOL scores reported were 15.0±6.69 among infants (IDQOL); 16.4±7.25 among children (CDLQI), and 15.5±7.59 among families (DFI).  The mean IDQOL, CDLQI and DFI scores were higher in patients with severe AD (16.7±6.66, 18.4±6.99, and 17.5±7.53, respectively) than among those with moderate AD (13.9±6.49, 15.2±7.14, and 14.2±7.35, respectively). A large proportion of respondents experienced extremely large effect of QOL scores (scoring 19 to 30), including 35.6% of infants, 44.0% of children and 39.1% of families. There were also large differences between the reported QOL from different countries. CONCLUSIONS: The study found that moderate to severe AD affected the QOL of the majority of patients and their families among respondents in the countries surveyed.