OBJECTIVES: Remote monitoring (RM) is useful in chronic diseases, but evidence is scarce in home dialysis. Sharesource™, a two way connectivity platform with RM capabilities, should enable earlier intervention and healthcare savings. This abstract describes a simulation study designed to estimate the type and importance of the savings. METHODS:  This study used an approach similar (although in a virtual environment) to that for diagnostic tests, i.e., additional information impact on treatment pathways. Automated peritoneal dialysis (APD) patient profiles (e.g., therapy non-compliance, fluid overload, etc.) were developed by a group of in-house nephrologists and nurses experienced in managing APD patients. Each patient profile was developed in 2 scenarios: “with RM” information (treatment data, blood pressure, weight) and “without RM”. Nephrologist (US=4, Germany=3, Italy=2) experts in managing APD patients validated the “without RM” resources. The “with RM” resources were evaluated by 15 (US=7, Germany=4, Italy=4) APD teams (1 nephrologist & 1 nurse). Resources were compared with t-tests. RESULTS: Patient profile development required several rounds of individual and group reviews over a 6 month-period to ensure clarity of clinical event sequence and clinician management response. During the process, 8 profiles were abandoned, leaving 12 profiles for the simulation. Recruitment of experts and APD teams was moderately easy, the biggest hurdle was contract signature in some countries (e.g., Italy). Participants submitted responses, usually within two weeks. Overall, results indicate that RM could avoid 49-75 healthcare resources (4.1-6.2 per patient profile), including clinic calls/visits (48-72), but also hospitalizations (2), emergency room visits (3.5-5) and transfer from APD to in-center hemodialysis (1-2.25). These patient profiles were perceived as representative of 17-37% of the APD patient population. CONCLUSIONS: This simulation was a rapid and affordable way of estimating the type and importance of potential reductions in healthcare resource consumption to be expected from RM in APD patients while waiting for real-world evidence.