OBJECTIVES: Clinical guidelines, guidances and technical guidances provide information to healthcare and other relevant professionals in order to inform decision-making for a particular area of public health or health and social care. Over the last few years there has been an increasing trend of using real world data as evidence to inform the recommendations for such documents. However, limited evidence exists regarding the extent to which such studies have directly impacted the NHS and other public health and social care systems. The aim of this review is to identify guidelines or guidances published from 2000 onwards in England which have referenced studies using data from the Clinical Practice Research Datalink (CPRD). METHODS: The methodology recommended by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed.  Four databases (The National Institute for Health and Care Excellence Evidence Search, PubMed, Embase and the National Clinical Guideline Centre) were searched. Documents of interest were identified through a search algorithm containing keywords relevant to CPRD and the General Practice Research Database (GPRD). A search diary was maintained detailing the databases and the inclusion/exclusion decisions. Exclusion criteria included guidelines not applicable to the UK, not available (commonly under review), and duplicates. RESULTS: Following the PRISMA search strategy, 271 documents were identified. After screening and assessment for eligibility, 21 guidelines/guidances were included. There were 25 different CPRD studies referenced in one or more documents. CONCLUSIONS: Identified guidelines/guidances covered a variety of specific conditions (e.g. Gout, Osteoporosis) and treatments (e.g. oral contraceptives, opioid substitution therapy (OST)). Further expected results will explore the range of treatment areas and time trends. This review serves as a case study on how research using real world evidence can influence and benefit practice.