OBJECTIVES:  Persistently stubborn infant mortality rates across the world have prompted the use of mobile technologies to assist in vaccine adherence. This systematic review attempts to assess the efficacy of a mobile phone technology in delivering timely infant immunisation reminders and ensuring compliance and follow-up rates. METHODS: Studies were identified based on pre-specified criteria from two journals (BMJ and Lancet) and three databases (PUBMED, Google Scholar and Cochrane). The articles were screened for PICO parameters and subsequently short-listed when they included the desired target population, namely infants and mothers and used the methodology of RCTs. Biases on account of dropouts, selection and blinding methods were taken into consideration. Risk ratios were analysed for the review using a forest plot and bias graphs. RESULTS: Total of 71 studies were identified based on results, of which 3 duplicates were excluded. Of remaining 68, 43 abstracts were excluded based on the results. Remaining 25 were screened for PICO parameters and finally 6 studies were found relevant for this HTA. The studies, published between 1996 and 2014, recorded the participation of 5999 infants and mothers across 5 clinic based interventions and 1 province-based intervention. A risk ratio of 0.67 indicates that the mobile-based intervention is 45% more effective than the control, suggesting the former to be a crucial measure to improve outcome measures such as timeliness of immunisation and increased infant vaccine awareness. CONCLUSIONS: Our analysis suggests that the use of mobile technologies could marginally improve compliance in the intervention groups, even if they do not affect the overall immunisation rates. The evidence also shows that incorporating this scheme into an existing health system requires a small investment that could potentially result in sizeable gains in reducing infant and neonatal mortality and morbidity, particularly in resource-limited settings.