OBJECTIVES: Neuro-behavior problems were found in an increasing number of children worldwide in recent one decade. Few studies showed that early exposure to environment hormones, which is transmitted from mothers’ exposure to these substances during pregnancy, can disrupt children’s development and their behaviors. Some studies have been done to find out the effect of phenols’ exposure in prenatal period on the development of neuro-behavior, but there has been no conclusive results yet. This study aims to explore the association of prenatal exposure to phenols (bisphenol A, nonylphenol, and octylphenol) and neuro-behavior development in school-aged children. METHODS: We conducted a prospective Taiwan Birth Panel Cohort Study in which 483 mother-child pairs were enrolled. We analyzed the association between phenols concentration in umbilical cord blood and the scores of SNAP-IV, CBCL and SDQ rated by children’s caregivers when they were 7 years old. Finally, 149 child’s neuro-behavior development ratings scales were collected. We used Taiwan’s standard norm to interpret the original scores. As for correlation analysis, multiple linear regression was adopted to adjust the potential confounders, including maternal education years, family’s annual income, postnatal environmental to tobacco smoke exposure and gender. RESULTS: The association of early exposure to phenols and neuro-behavior development in school-aged children was only significant in few domains. The level of BPA in umbilical cord blood was significantly correlated with the oppositional domain in SNAP-IV(β=-0.08; 95% confidence interval (CI) : -0.286-0.1261; p=0.041) and the thought problem domain in CBCL(β=-0.268,; 95% CI : -0.567-0.0314; p=0.0446). The level of octylphenol in umbilical blood was significantly correlated with the peer interaction domain in SDQ, (β=0.1552; 95% CI :-0.217-0.5269; p=0.0308). CONCLUSIONS: This study shows that the association between prenatal exposure to phenols and neuro-behavior development in school-aged children is not significant in most domains of SNAP, CBCL, and SDQ rating scales.