OBJECTIVES: Idiopathic Pulmonary Fibrosis is a rare fatal respiratory disease characterized by a decline in lung function leading to deliberating limitations on activity which may negatively impact health-related quality of life. There is limited research on the outcome measures of IPF. Systematically reviewed all the outcome measures used in the treatment of IPF and critically appraise the measures used to evaluate the treatment result of IPF with the aim of drawing conclusions regarding the suitability of these measures. METHODS: Conducted a systematic review from Medline, EMBASE, EBM reviews, NICE, HTA written in English between 2008 and September 2014. Data was extracted from the citation applying efficacy, safety and health-related quality of life outcomes in the selected studies.  RESULTS: Lung function test is the most commonly used outcome measures. Exercise capacity and health-related quality of life are the secondly common outcomes used.  Then mortality or acute exacerbation are the third most commonly used outcome measures. Dysponea and health related quality of life measures have at least two scales of measures used at the same time. Each of the measurements are used either alone or in combination. The scale of measurement of mortality, survival, acute exacerbation vary accordingly. Mortality and survival are the most important outcomes to evaluate the efficacy of the treatment. Some studies used both of the mortality and survival, some used either one. CONCLUSIONS: The appropriate outcome measures in IPF are lung function test as Forced Vital Capacity 10% relative change at one year, exercise capacity 6-MWT with saturation measures, St. George’s Respiratory Questionnaire along with SF-36. Overall survival combines with progression-free survival represent important treatment targets in IPF. All these measures are suitable and essential measures should be considered when investigating the new therapies. Assessing dysponea scale with UCSD and HRCT scanning are appropriate but not necessary outcome measures.