OBJECTIVES: The safety and effectiveness of Selective Retina Therapy as a procedure that induces the regeneration of the retinal pigmented epithelial cells by selectively destroying only the retinal pigmented epithelial cell in patients with retinal diseases were assessed. METHODS: Assessment was made on the Selective Retina Therapy by extending the range of patients to be subjected to this technology by including macular edema and central serous chorioretinopathy patients. Intervention procedures included a broad range of technologies that selectively damages the retinal pigments and all devices without limitation were selected in assessment of the safety and effectiveness of this technology. For information search, 8 domestic databases including Korea Med and overseas databases including Ovid-Medline, Ovid-Embase and Cochrane Library were used. A total of 55 relevant literatures were searched through the use of search words related to ‘selective retina therapy’.  As the result, a total of 7 literatures were included in the final assessment by applying the criteria for selection and exclusion to the 28 literatures after having excluded 27 overlappingly searched literatures. Each of the stages from literature search to application of selection standards and extraction of data were carried out independently by 2 assessors under the deliberation by the Sub-committee. RESULTS: Although there is no safety problem with the Selective Retina Therapy when implemented on central serous chorioretinopathy patient, there is no literature that made report on the key effectiveness variable of the Therapy,making the assessment of the effectiveness of this technology difficulty. CONCLUSIONS: Therefore, this technology was assessed to be at a stage that requires further researches (Recommendation rating of D, Classification as technology in research stage i).