REAL-WORLD IDENTIFICATION OF EUROPEAN PATIENTS WITH STATIN-ASSOCIATED SYMPTOMS- CLINICAL PRACTICE COMPARED WITH CLINICAL GUIDELINES
Author(s)
Hovingh GK1, Gandra SR2, McKendrick J3, Dent R2, Wieffer HM3, Catapano AL4, Oh P5, Rosenson RS6, Stroes ES7
1Academic Medical Center, Amsterdam, The Netherlands, 2Amgen, Inc., Thousand Oaks, CA, USA, 3PRMA Consulting Ltd, Fleet, UK, 4University of Milan and IRCCS Multimedica, Milan, Italy, 5Toronto Rehabilitation Institute, Toronto, ON, Canada, 6Mount Sinai Icahn School of Medicine, New York, NY, USA, 7Academic Medical Center, the Netherlands, Amsterdam, The Netherlands
OBJECTIVES: To establish whether identification of patients with statin-associated symptoms (SAS), particularly muscle-related symptoms (MRS) in real-world practice is aligned with the latest clinical consensus. METHODS: A web-based survey was conducted in France, Germany, Italy, the Netherlands, Poland, Spain, Sweden, and the UK in February–March 2014. Sixty clinicians per country answered questions about clinical criteria used to identify patients with SAS. These criteria from real-world practice were compared with those recommended in the 2015 European Atherosclerosis Society Consensus Panel Statement (EASCPS) to explore their alignment. RESULTS: Overall, 319 clinicians (76% cardiologists) completed the survey. Almost all clinicians (average 98%; range across countries [RAC] 97–100%) saw and considered MRS in patients receiving statins to indicate SAS. Across countries, an average of 69% of clinicians reported testing for elevated creatine kinase (CK) levels in all patients newly prescribed statins; an average of 52% reported testing in patients who displayed MRS. On average, 77% of clinicians (RAC 68–85%) reported trying ≥2 statins before considering MRS to be SAS; 65% (RAC 57–73%) tried ≥3 statins. Most clinicians (average 74%; RAC 63–85%) reported rechallenging patients with the same statin to confirm whether MRS were SAS. Of those who did not rechallenge, 61% (RAC 50–67%) reported discontinuing the statin to test whether MRS resolved, and an average of 38% (RAC 32–45%) reported using a combination of rechallenging, discontinuing, and lowering the dose of statin to confirm SAS. Of the reported criteria used for determining SAS, CK testing upon MRS and trial of ≤3 statins are consistent with the latest EASCPS, although routine CK testing and statin rechallenge are not fully consistent. CONCLUSIONS: This survey suggests that the clinical criteria used to identify patients with SAS across eight European countries are broadly consistent with the current clinical consensus in Europe.
Conference/Value in Health Info
2015-11, ISPOR Europe 2015, Milan, Italy
Value in Health, Vol. 18, No. 7 (November 2015)
Code
PCV153
Topic
Health Service Delivery & Process of Care
Topic Subcategory
Prescribing Behavior, Treatment Patterns and Guidelines
Disease
Cardiovascular Disorders
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