QUANTIFYING THE SHORT-TERM IMPACT OF CHANGES IN HBA1C, WEIGHT AND INSULIN REGIMEN ON HEALTH RELATED QUALITY-OF-LIFE
Author(s)
Evans M1, Ridderstråle M2, Jensen HH3, Bøgelund M4, Jensen MM5, Ericsson Å6, Jendle J7
1University Hospital Llandough, Cardiff, UK, 2Steno Diabetes Center, Gentofte, Denmark, 3Incentive, Holte, Denmark, 4Novo Nordisk Ltd., Gatwick, United Arab Emirates, 5Novo Nordisk, Copenhagen, Denmark, 6Novo Nordisk Scandinavia AB, Malmö, Sweden, 7Örebro University, Örebro, Denmark
OBJECTIVES: Understanding immediate improvements in health related quality-of-life (HRQoL) due to better glycaemic control may help inform decisions relating to the management of diabetes. This study investigated the short-term impact on HRQoL associated with HbA change, body weight change, and the complexity of treatment regimen, using time-trade-off (TTO) methodology METHODS: The study was performed in three stages: 1) Qualitative telephone interviews with people with type 2 diabetes (T2D) in Denmark who experienced a decrease in their HbA level; 2) A validation survey with people with T2D in Denmark to obtain quantifiable knowledge on the short-term effects of a change in HbA levels; 3) TTO survey using health states based on results from stage 2. ‘Not well-controlled diabetes’ reflected an HbA average of 11.6%, and ‘well-controlled diabetes’ an HbA average of 7.4%. All other health states were based on ‘well-controlled diabetes’. These health states implied change in insulin regimen and change in weight. Respondents were either adults with T2D (Sweden) or from the general public (UK and Denmark) and were separately randomly allocated to evaluate 6 of the 10 health states through an internet-based survey. RESULTS: In total,
Conference/Value in Health Info
2015-11, ISPOR Europe 2015, Milan, Italy
Value in Health, Vol. 18, No. 7 (November 2015)
Code
PDB108
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Diabetes/Endocrine/Metabolic Disorders