PSYCHOMETRIC VALIDATION OF THE NEW INTERNATIONAL QUESTIONNAIRE TO ASSESS HEALTH-RELATED QUALITY OF LIFE (HRQL) SPECIFIC TO VIRAL HEPATITIS C- PROQOL-HCV

Author(s)

Duracinsky M¹, Armstrong A², Herrmann S³, Lalanne C¹, Galano E⁴, Da Silva MH⁴, Carrieri PM⁵, Chassany O¹
¹University Paris-Diderot, Sorbonne Paris Cité, Paris, France, ²Australian Institute of Family Studies, Melbourne, Australia, ³Murdoch University, Murdoch, Australia, ⁴Centro de Referência e Treinamento DST/Aids, Sao Paulo, Brazil, ⁵INSERM, Marseille, France

Presentation Documents

PIN90--strong-u-duracinsky-m-u-sup-1-sup-strong-armstrong-a-sup-2-sup-herrmann-s-sup-3-sup-lalanne-c-sup-1-sup-galano-e-sup-4-sup-da-silva-mh-sup-4-sup-carrieri-pm-sup-5-sup-chassany-o-sup-1-sup-br-sup-1-sup-university-paris-diderot-sorbonn ...

OBJECTIVES: To validate a new international questionnaire to assess Health-Related Quality of Life (HRQL) in patients living with HCV. Existing tools used in HCV were mostly generic and missing important concepts such as impact of the treatment. METHODS: RESULTS: Sample characteristics: 57% men, 52 years, 80% vocational level and higher, 35% living alone. Regarding comorbidities and treatment status: 35% co-infected with VIH (95% under ART), 15% not treated, 25% undergoing interferon, 35% ribavirine, 43% Direct-Acting Antivirals (35% without associated interferon); 27% depressive (71% treated). The PROQOL-HCV questionnaire was reduced to 38 items spanning 7 dimensions scored on a 100-point scale: Physical Health (PH, 6 items, α=0.90), Emotional Health (EH, 9 items, α=0.93), Future Uncertainty (FU, 6 items, α=0.79), Intimate Relationships (IR, 3 items, α=0.86), Social Health (SH, 3 items, α=0.47), Cognitive Functioning (CF, 3 items, α=0.80), and Treatment Impact (TI, 8 items, α=0.61). Pearson correlations of PROQOL-HCV dimension with the EQ5-D (general health) and SF-12 mental and physical composites were in the acceptable range. The PH dimension was negatively correlated to the number of bothersome symptoms (p<0.001). Lower HRQL (PH, EH, CF) was reported in women (p<0.01), depressive patients (p<0.001), patients under interferon (p<0.01, except CF), patients without treatment (p<0.01). CONCLUSIONS: PROQOL-HCV questionnaire is valid and contains new dimensions such as Intimate Relationship, Social Health and Treatment impact.

Conference/Value in Health Info

2015-11, ISPOR Europe 2015, Milan, Italy

Value in Health, Vol. 18, No. 7 (November 2015)

Code

PIN90

Topic

Patient-Centered Research

Topic Subcategory

Patient-reported Outcomes & Quality of Life Outcomes

Disease

Infectious Disease (non-vaccine)

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Patient-Centered Research

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