OBJECTIVES: The number of cancer survivors is growing due to progression in diagnosis and treatment. Approximately half of cancer survivors are at working age, however many of them do not return to work. One of the reasons is a disability of cancer survivors. Although cancer related disability is usually more severe compared to disability due to other diseases, real-life data showed up to 85% of disabled cancer survivors may return to work after comprehensive rehabilitation programs. The aim of this study was to estimate potential savings to EU economy due to return to work of disabled cancer survivors. METHODS: Data on indirect cost of a cancer related disability were calculated based on Luengo-Fernandez at al. study and our own estimation of a contribution of disability to indirect cost related to morbidity. Disability structure i.e. percentage of a partially disabled cancer survivors, was adopted from Polish Social Insurance Institution data (we assumed that population with complete disability or inability for independent existence can’t return to work). Presenteeism and absenteeism in cancer survivors were adopted from our previously published studies. RESULTS: We estimated the indirect cost of cancer due to disability in EU at the amount of 4223.2 million EUR. However partial disability account for approx. 20-25% of this sum and reduces potential savings to the amount of 844.6–1055.8 million EUR. Further correction, taking into account the efficacy of rehabilitation programs (up to 85%), reduces this savings to 717.9–897.4 million EUR. Considering the  loss of productivity due to sickness absence and presenteeism measured in cancer survivors’ population (19.1% and 37.3% respectively) potential savings for  EU economy due to return to work of cancer survivors with a disability are calculated at the amount of 364.2-455.2 million EUR. CONCLUSIONS: Indirect cost of cancer related disability can be reduced, but probably only to a small extent.