OBJECTIVES: Adverse drug reactions (ADRs) are contributing to poor medication adherence, delayed treatment, poor quality of life and increased treatment cost in cancer patients. This study was conducted to detect and monitor adverse drug reactions (ADRs) through spontaneous reporting and contineous monitoring system in patients receiving cancer chemotherapy. METHODS: A prospective study was conducted at specialty cancer hospital for a period of six months. Clinical pharmacists followed the patients admitted to different wards of a study hospital. Medical records of the patients were reviewed and patients and their care givers were interviewed to identify ADR. Identified ADRs were discussed with concerned oncologists, documented electronically and assessed further. RESULTS: A total of