OBJECTIVES: The objective of this study is to assess the characteristics and health care resource utilization of patients diagnosed with neoplasm of colon. METHODS: A large US administrative retrospective claims database was used to identify patients diagnosed with neoplasm of colon and were taking treatment from January 2001 to December 2013 were included in the study. All patients were ≥ 18 years of age and continuously enrolled in the same health plan at least for a year. Descriptive statistics and chi-square tests were performed on the data. RESULTS: There were a total of 6,346 patients that met the study inclusion criteria. Of these, 3,713 (58.50%) patients were <65 years of age (adult) and 2,633 (41.50%) were ≥65 years of age (geriatric). The mean ages of patients in each group were (54.43±7.79 vs 74.41±5.59 years, p<0.05). There were no significant difference (p>0.05) in the distribution of males (52.1% vs 50.8%) and mean length of stay (1.14±1.56 vs 1.14±1.81 days) between the two age groups. There were more patients in adult group in the MidWest (28.4% vs 22.9%) and South (40.6% vs 37.4%) regions compared to ≥ 65 years of age group (p<0.05). On average, patients were continuously enrolled in the same health plan for 64.55±36.48 vs 64.75±31.64 months and submitted 641.68±596.15 vs 657.84±568.94 claims with no difference (p>0.05) between the two groups. Patients on average were charged by the provider $502.33 ± 1963.83 vs $473.13 ± 1891.67 for their colon cancer treatment (p<0.05) during the study period. However, the paid amount by the health plan was $226.33 ± 1046.81 vs $129.95 ±612.63 with a significant difference between the groups (p<0.05). CONCLUSIONS: The majority of the patients was adults and were charged higher amount by the provider for the treatment of neoplasm of colon.