OBJECTIVES: Psychological, social, wellbeing factors and adherence emerged as key issues for measuring the HIV-infected patients quality of life (QoL). In the literature, but in Italian evidences in particular, there is a lack of indication concerning i) a specific “country-oriented” QoL measure, ii) its relationship among immunological (CD4) and virological (VL) status and iii) determinants and predictors of HIV-patients QoL. The aim of the study was to examine the QoL, adherence, wellbeing, depression, CD4 and VL, in an Italian unselected cohort of patients receiving stable antiretroviral treatment. METHODS: A multicenter, prospective study was conducted, involving 3 Infectious Diseases centers in Lombardy Region. Two groups of patients were considered, depending on the therapeutic strategy characteristics: Multiple Pill Regimens (MPR) and Single Tablet Regimens (STR). Validated and self-reported questionnaires (ISS-QoL, EQ-5D-3L and CES-D) were administered to collect social and clinical data, QoL measure and adherence information, both at baseline and follow-up (6 months). The correlations between i) perceived QoL and the above mentioned variables, ii) determinants and/or predictors of the QoL, were investigated. RESULTS: