OBJECTIVES: The present study aimed at investigating the impact of mandatory clinical clerkship courses on fifth year pharmacy students' attitudes and perceived barriers toward providing pharmaceutical care (PC). METHODS: A cross-sectional survey was conducted among 5^th year pharmacy students undertaking mandatory clinical clerkship in the University of Gondar, Ethiopia. A pharmaceutical care attitudes survey (PCAS) questionnaire was used to assess the attitude (14 items), commonly identified drug-related problem/s (1 item) during clerkships, and perceived barriers (12 items) toward the provision of PC. Statistical analysis was conducted on the retrieved data. RESULTS: Among the total of 69 clerkship students, 65 participated and completed the survey (94.2% response rate). Overall, 74.45% of participants had positive attitude toward PC provision. Almost all respondents agreed that the primary responsibility of pharmacists in the healthcare setting was to prevent and solve medication-related problems (98.5%), practice of PC was valuable (89.3%), and the PC movement will improve patient health (95.4%), respectively. Unnecessary drug therapy (43%), drug-drug interactions (33%), and non-adherence to medications (33%) were the most common drug-related problems identified in wards. Highly perceived barriers for PC provision included lack of a workplace for counseling in the pharmacy (75.4%), a poor image of pharmacist's role in wards (67.7%), and inadequate technology in the pharmacy (64.6%). Lack of access to a patient's medical record in the pharmacy had significant association (P<0.05) with PC practice, performance of PC during clerkship and provision of PC as clinical pharmacists CONCLUSIONS: Students attending the new clinical pharmacy program in Ethiopia have a good attitude toward pharmaceutical care. However, the barriers to pharmaceutical care need to be addressed by integrating PC provision with pharmacy practice.