OBJECTIVES: Diabetic foot ulcer (DFU) is a common complication of diabetes and not only an important factor of mortality among patients with diabetes but also decreases quality of life. Several clinical trials showed that patients with foot ulceration have significantly decreased HRQoL as compared to those without DFU. Most of these studies used SF-36 for quality of life measures, however it is suggested that the results of this HRQoL survey may be confounded by non-foot complications of diabetes. The short form of Diabetic Foot Ulcer Scale (DFS-SF) is a condition-specific tool, providing comprehensive measurement of DFU impact on patients’ QoL. The Polish translation of DFS-SF has undergone a full linguistic validation process and showed good psychometric performance in patients with DFU. The purpose of this study was to investigate the influence of ulcers healing process on HRQoL. METHODS: Assessment of healing process impact on HRQoL was performed in patients with active DFU. Wound healing assessment was carried out on two control visits separated with a 6-months period, on the basis of wound diameter measurements and PEDIS score. Hypothesis testing was conducted using the Student’s t-test (α=0.05). RESULTS: Data on 120 patients were analyzed (mean age: 61.1 years, male: 73%, type 2 diabetes: 87%). The average ulcer size on first visit was 5.6 sq cm, and reduced significantly to 2.7 sq cm on second visit. Improvement in all six DFS-SF subscales was observed, statistically significant in physical health, worried about ulcers/feet and bothered by ulcer care subscales. Complete ulcer healing was observed in 42 patients. All six DFS-SF subscales showed greater improvement in this subpopulation compared to population without complete ulcer healing, although the difference was not significant. CONCLUSIONS: In previous study we identified weak negative correlation between ulcer size and HRQoL. This study showed that ulcers healing process has significant impact on HRQoL of DFU patients.