OBJECTIVES: To provide an estimation of expected lifetime numbers, risks, and burden of fractures for 50-year old Chinese women. METHODS: A discrete event simulation model was developed to simulate the lifetime fractures of 50-year old Chinese women at the average risk of osteoporotic fractures. Main events in the model included hip fracture, vertebral fracture, wrist fracture, humerus fracture, and other fracture. Input fracture risks were calculated with the FRAX® tool and the declining exponential approximation of life expectancy (DEALE) approach. Simulations of 50-year old Chinese women without fracture risks were also carried out to determine the burden of fractures. RESULTS: For a 50-year old Chinese woman at the average risk of fractures, there are 0.135 (95% CI: 0.134-0.137) hip fractures, 0.120 (95% CI: 0.119-0.122) vertebral fractures, 0.095 (95% CI: 0.094-0.096) wrist fractures, 0.079 (95% CI: 0.078-0.080) humerus fractures, and 0.407 (95% CI: 0.404-0.410) other fractures expected for the rest of her life. The residual lifetime risks of any fracture, hip fracture, vertebral fracture, wrist fracture, humerus fracture, and other fracture for a 50-year old Chinese woman are 37.36%, 11.77%, 10.47%, 8.61%, 7.30%, and 27.80%, respectively. The fracture-attributable excess quality-adjusted life year (QALY) loss and lifetime costs are estimated at 0.11 QALYs (95% CI: 0.00-0.22 QALYs) and US$714.61 (95% CI: US$709.20-720.02), totaling to a net monetary benefit loss of US$1,104.43 (95% CI: US$904.09-1,304.78). CONCLUSIONS: Chinese women at the age of 50 years old are at a high risk of any osteoporotic fracture. The expected economic and quality of life burden attributable to fractures among Chinese women is substantial.