OBJECTIVES: Accurate determination of the progression degree in colon cancer is of paramount importance for the decision making in treatment policy. However, it had been difficult to extract the exacerbation status from the real-world data. The objective of the study was to develop the model to determinate the progression degree using the insurance benefits data in Japan.  METHODS: We conducted analyses using claims data provided by Medical Data Vision Co., Ltd. We extracted target patients by the criteria those who meets all of the following conditions; at least one colon cancer diagnosis (ICD-10 code C18~20), tractable from the first diagnosis to death, and have at least 365 days of observation. We set the progression degree as a scale from 0% to 100%. The degree of 100% indicates the patient death. For the first diagnosis, the scale was adjusted based on the patient’s condition. We have developed a linear regression model by using the medication frequency of ATC codes as independent variables and the logit of progression degree as a dependent variable.  RESULTS: