OBJECTIVES: The recently-observed trend towards  the stroke patients in raises the economic concerns. Cost-of-illness (COI) analysis is the main method of providing an overall view on the economic impact of a disease. the main objective of this study is to estimate the economic burden of stroke. METHODS: The economic burden of stroke was estimated from a societal perspective with an incidence approach.Data were collected from clinical registries and 100 patients were included. In the cost calculations, both direct and indirect costs were estimated. RESULTS: Men (78%) consumed more acute care in hospitals, than the  women (22%). Younger patients (59%) brought a significantly higher burden on society compared with the older patients due to the loss of productivity and the increased use of resources in health care.41% of patients who have hypertension and 45% of patients with alcohol and smoking habits have more prone to stroke rather than the patients with other habits and comorbidities.56% of patients have the hospital stay of 5-10 days and 52% are using 4-7 medicines per day. From the study results ,average  direct medical costs and direct nonmedical costs and Indirect costs were found to be 2819 ,705 and 754 rupees. In essence, majority of the costs for stroke care fall on the hospital,than the  long-time care and informal care costs  and productivity loss. CONCLUSIONS: The result of this study can be used for further development of the methods for economic analyses as well as for analysis of improvements and investments in health care. This aspect highlights the enormous importance, for our healthcare service, to invest more in prevention. This cost analysis highlights the importance of clinical pharmacist to set up significant prevention programs  on selected,high-risk population to reduce the economic burden of stroke, which is mostly attributable to hospital and inpatient rehabilitation costs immediately after the acute episode.