OBJECTIVES: In India, Human immunodeficiency virus (HIV) infected patients lacks knowledge on highly active antiretroviral therapy (HAART) leading to non-adherence.The study was conducted to assess the effect of pharmacist counseling on HAART and Patient reported outcomes related to Knowledge, Attitude, Belief and Practice (KABP) behavior. METHODS: A prospective study was conducted with Institutional Ethics Committee Approval, at tertiary care teaching hospital, from October 2011 to June 2012. People living with HIV (PLH) were counseled by a pharmacist with validated (KABP) questionnaires and data scores of (KABP) responses were assessed at the base-line, pre and post counseling.Counseling was on safe use of HAART, significance of HAART adherence. Pearson chi-square test was used to compare baseline Pre- KABP and Post- KABP responses with follow-ups. RESULTS: A total 120 PLH (89 males, 31 females) were counseled. The PLH were counseled on tenofovir + emtricitabine + efavirenz followed by zidovudine + lamivudine + nevirapine therapy. At the baseline 94(78.3%) knew the mode of HIV transmission and 60(50%) were not aware about the content of HAART. Aftet pharmacist counseling, 58.3% (p<0.001) of patients knew about the content of HAART. Knowledge score was (p<0.001) higher in the literate group (51.7%) compared to Illiterate group (48.3%). Patients attitude, beliefs related to HAART, were found to be (p<0.05) and 78% (p<0.001) patients were aware that lifelong HAART therapy is needed. In comparison, from base line counseling responses of (33%) to post counseling responses of (67.5%) of PLH realized that HAART improves immunity CONCLUSIONS: Pharmacist counseling removed social stigma, and increased self-efficacy beliefs to maintain adherence to HAART.