OBJECTIVES: Prior to February 2013, price management within Astellas Pharma Europe Ltd. was done manually using an Excel database. The system was labour intensive, slow to update, and prone to error. We developed an innovative web-based pricing information management system to address the shortcomings of the previous system. METHODS: A secure web-based system for submitting, reviewing and approving pricing requests was developed for use by 21 affiliates in 40 countries in Europe, Middle East and Africa. The aims of the new system were to: (i) reduce time/effort to approve price change requests; (ii) reduce the risk of using incorrect/unapproved prices; (iii) improve the visibility of pricing data to affiliates; (iv) improve approval process compliance. The system was designed to: track all pricing applications and approval status; update approved pricing information automatically; provide fixed and customisable reports of pricing information; collect pricing and reimbursement rules from each country; validate pricing and reimbursement rules monthly. The system was piloted by 3 affiliates (4 users). RESULTS: The web-based system was introduced in March 2013, and has 246 users. The number of pricing applications/year increased from