OBJECTIVES: To evaluate disease burden, clinical and patient-reported outcomes and healthcare costs of patients admitted to hospital for management of plaque or erythrodermic psoriasis. METHODS: This observational study enrolled 61 eligible patients from 107 hospital stays across 9 UK hospitals.  Sites recorded Psoriasis Area Severity Index (PASI) at admission and discharge, psoriasis treatments, and length of stay (LOS). Patients reported psoriasis-related symptoms, health status (SF-12v2, EQ-5D-3L), mood (HADS), productivity (WPAI), and dermatology-related quality of life (DLQI) at admission, and also reported psoriasis-related symptoms, EQ-5D-3L, and DLQI at discharge. An algorithm assigned cost/hospital stay. Descriptive statistics are based on those responding to each item. Statistical significance evaluated at the 0.05 level. RESULTS: Mean age was 45.5 years; 50.8% were male. Mean time since psoriasis diagnosis was 20.0 years. Most (78.7%) had ≥1 previous psoriasis-related hospitalization. Mean number of physician-diagnosed co-morbid conditions was 2.5. At admission, mean SF-12v2 Physical and Mental component summary scores were 35.4 and 32.1, respectively; mean HADS scores were 9.7 (anxiety) and 9.6 (depression) indicating substantial impairment. Forty-five percent reported changing job, role, or position at work due to psoriasis. Mean WPAI activity impairment at admission was 68.7%; among the 35.1% employed for pay, mean WPAI work impairment was 79.2%.  Mean PASI improved from admission to discharge (25.2→12.1; p<0.0001). Also, improvement was seen at discharge for EQ-5D-3L (0.34 →0.60), DLQI total score (20.1→12.0), and psoriasis symptom scores (all p<0.05). Mean (range) LOS was 17.0 (2,71) days; for 8 patients achieving a 75% reduction in PASI (PASI75),  mean LOS was 18.1 vs. 13.1 days for 27 patients not achieving PASI75 (p=0. 11). Mean (SD) cost/hospital stay was £4,875 (±£3,096). CONCLUSIONS: Disease burden, LOS and cost are substantial among patients hospitalized for psoriasis. On average, patients improved during their hospital stay. Nonetheless, they reported suboptimal clinical and patient-reported outcomes at discharge.