OBJECTIVES:  Our study aims to investigate any additional domain more specific to Asian countries while retaining the existing domains of EQ-5D centered on Western society. After identifying candidate domains, we examined the level of health in a general population and compared the results from EQ-5D with additional domains and the ones from original EQ-5D. METHODS: We organized candidate domains that could be included in the preference-based HRQoL instrument after reviewing the HRQoL measures and conducted focus group discussion (FGD) targeting the general public. To examine the practicality of the HRQoL measure, we conducted the survey with nationally representative 1,000 adults aged 19 to 69 in Korea. In order to assess the influence of each domain on HRQoL, we performed quantile and logistic regression analyses using the visual analog scale (EQ-VAS) and self-rated health as a dependent variable. RESULTS: As the result of FGD, vision, hearing, speaking, memory, sleep, vitality, happiness, and close relationship were established as additional measurement domains. Through survey, the mean EQ-VAS score was 80.11 (standard deviation 12.84). Among those who did not have problems in the EQ-5D’s 5 domains, the number of people who reported problems in vitality was 244 (37.2%), happiness 130 (19.8%), and sleep 71 (10.8%). Among them, the number of people who described their self-rated health from “good” to “poor” was as high as 76 (11.6%). In the quantile regression model, pain/discomfort and anxiety/depression from the EQ-5D domains and vision, sleep, vitality, and happiness from the additional domains showed statistical significance. Also, the explanatory powers increased. Among the additional 8 domains, the group with vitality, sleep and happiness had a higher probability of having good self-rated health. CONCLUSIONS: Vitality, sleep and happiness were significant additional factors for new HRQoL domains. However, since many other factors may exist outside of HRQoL domains, various aspects should be considered when developing a new tool.