OBJECTIVES: Estimates on the number of adult caregivers (CGs) vary in the literature.  The aim of this analysis is to profile CGs across eight countries relative to non-caregivers (non-CGs) with respect to demographics, quality of life (QoL), CG burden, etc. METHODS: This analysis utilized cross-sectional data from the 2013 National Health and Wellness Survey (NHWS).  Results from eight countries (US, France, UK, Germany, Italy, Spain, Japan, and urban China) were assessed.  A stratified random sampling was used to ensure representativeness to the adult population (age 18 and over).  NHWS asked adults if they are caring for an adult relative with a health condition, along with the Caregiver Reaction Assessment (CRA) questions.  Comparisons were conducted by country to profile CG demographics, QoL, depressive symptoms (PHQ9), and CG burden relative to non-CGs. RESULTS: NHWS results showed adults in Spain (11.6%) and China (10.6%) were most likely to be CGs; adults in Japan were the least (4.9%).   Alzheimer’s disease/dementia was the top condition of the patients (except in China, where osteoarthritis ranked highest).  Other notable conditions were: cancer, stroke, osteoarthritis, and bipolar disorder.  Half of CGs were women, except in China (44% were women). Overall, CGs were younger than non-CGs (mean age = 44.1 yrs vs. 46.3 yrs), especially in China (CG mean age= 38.9 yrs).  QoL scores (mental and physical, and SF6D) were lower among CGs vs. non-CGs.  CGs had higher rates of moderate-severe depression (26.2%) based on PHQ-9 scores vs non-CGs (13.7%). One-third of CGs said activities centered around the patient; one-fourth said finances were strained. CONCLUSIONS: Family members assume important roles when caring for an adult relative, which may negatively impact their own well-being and finances.  Profiling the differences of CG burden by country could help illustrate the need for interventions to minimize burden.