OBJECTIVES: To analyze  the cost variation of oral anti-diabetics of different generic drugs  sold at Jan Avushadhi and jeevanadhara  and Retail pharmacy  available  brand names of single compound and  combination compounds to evaluate the difference in cost ,  percentage variation of cost.  METHODS: Cost of  single  and combination compound drugs manufactured by different companies, in the same  strength, number and dosage form was  obtained from Current Index of Medical Specialties” July-October 2014 and jan avushdhi,jeevandharaa drugs were compared upto February -2015.  RESULTS: In Single compound drug  usage, among sulfonylurea group of drugs, Glibenclamide (2 mg) shows maximum price variation of 1980%,  while Glipizide (10mg) shows variation of 55.61%. In Biguanides & Thizolidinediones groups Of drugs Metformin (1000 mg) show Maximum  price variation is 125.37%, Metformin (500 mg)  leat variation is  30 % and Piglitazone (30mg)  show Maxmum variation 3060.97% and  least variation Pioglitazoe (15 mg)  is 3275 respectively. . In α-glucosidases inhibitor group of drugs,Miglitol shows maximum price variation of 135.50 % and Minimum variation is 41.93 %. Meglitinides group of drugs. In this group, Rapaglinide (0.5 mg) shows Maximum price variation of 79.25 % and Minimum variation is 60 % respectively. Dipeptidyl peptidase IV inhibitors (e.g., Sitagliptin), group Sitagliptin (100 mg) shows Maximum price variation of 902.3 %. In combination therapies Glibenclamide + Metformin (5 mg+ 500 mg) combination shows the maximum variation up to 2400 % and Glipizide + Metformin (2.5mg + 250mg) showed minimum price variation of % respectively. CONCLUSIONS:  study has concluded that the cost variation increases  when competition between the  manufacturing companies and generic companies. cost which company providing less cost and whether these drugs are available janavushadhi or jeevandhara or generic pharmacy shops. So that we can minimize the cost burden on consumers .