OBJECTIVES: Research on pain severity and health outcomes, especially health-related quality of life (HRQoL), is often done in a specific disease area examining specific domains within HRQoL. Although important, this research says very little about the relationship between general pain severity (across conditions) and domains of HRQoL. The purpose of this study was to investigate this relationship using a large sample of EU patients diagnosed with pain. METHODS:  Data came from the 2013 EU National Health and Wellness Survey (NHWS; n=62,000). The NHWS is a cross-sectional general health survey assessed yearly in the 5 EU (UK, France, Spain, Italy, and Germany). Those individuals who reported a diagnosis of one or more pain types were the focal subsample of this analysis (n=14,459). Patients’ HRQoL was assessed via the SF-36 and their pain in the past week was measured on an 11 point self-report scale from 0 “no pain” to 10 “pain as bad as you can imagine”. RESULTS: Initial descriptive results showed that there were large mean differences in SF-36 domain scores for those with a diagnosis of pain vs. those without. The largest differences were observed for the bodily pain (M=40.91 vs. 51.88, p<.001, d=1.06), general health (M=42.89 vs. 50.68, p<.001, d=.80), and role emotional (M=43.93 vs. 51.04, p<.001, d=.75) scales. With regard to pain severity in the past week, the strongest correlations were observed for the bodily pain (r=-.63, p<