OBJECTIVES: This article describes the epidemiological features of spread of HIV infection in the Republic of Kazakhstan.   We have examined gender-specific of HIV- infection in the Republic of Kazakhstan. As of December 31, 2013, 19 905 cases of HIV- infection have been registered in the country, 1933 persons of which were tested positive for AIDS, 1431 persons died. METHODS: All the cases of HIV- transmission in Kazakhstan for 26 years (1987-2013) have been analyzed. Statistical data was processed by means of BIOSTAT program.  Extensive, crude, age indexes were calculated based on the general methods of health statistics RESULTS: The prevalence of HIV in Kazakhstan is 86,5 out of 100 thousand people (0,09/), while the age group is people from 15 years old and older- 0,14/CONCLUSIONS: Epidemiological analysis shows that the number of HIV-positive is increasing, the largest part of them are young people at the age of 20 to 39 years old. The ratio of HIV-positive women has increased, the infection transmission route has changed- the heterosexual transmission is taking the leading position.