OBJECTIVES: Succinic acid as endogenous metabolite, has a wide range of applications in medical care. We conduct research on the development of new medicines based on succinic acid, ascorbic acid and rutin for the prevention and treatment of  influenza. A systematic review was carried out to perform a qualitative assessment of succinic acid adding in the various medicines and to determine of their pharmacological action.  METHODS: MEDLINE^®, EMBASE^®, Scopus, Cochrane Library databases and clinical trials registers between 1966 and Jun 2015 were performed. To analyze the RCT were selected and Review on the Study of the pharmacological action of drugs, which include succinic acid. Quality of evidence was assessed and each article was rated of quality.  RESULTS: Our study included 29 articles (23 RCT and 6 Review). The evidence varied in terms of: scope and years of research, type of treatment, study duration, sample size (<100 to> 500 patients). Generally, the mean age of included patients was middle. For pharmacological properties and by relevance RCT are grouped as follows: antigypoxic  action  were 7 RCT (2003-2013 years), improve iron absorption in the gastrointestinal tract - 6 RCT (1966-1974), hepatoprotective - 4 RCT (2013-2014 years). One RCT proves the efficiency of succinic acid used in gastroenterology (a combination with omeprazole, 2012), depression (2013), in transplantation (1993) at menopause (2008), renal failure (2013), to improve body temperature during surgery (2007). Analysis of  Review opens the new prospects for the use of succinic acid in cancer, diabetes and hepatitis C treatment. CONCLUSIONS: A comprehencive overview of  these studies estimated the evidence of succinic acid addition of the drugs. Succinic acid as endogenous metabolite, is a part of drugs of different pharmacological actions. These clinical trial results have been retrieved and give the possibility to develop of new drugs with succinic acid also in Ukraine.