A SYSTEMATIC REVIEW TO ASSESS THE ASSOCIATION BETWEEN THE USE OF ANTIDEPRESSANTS AND MALE-ONLY CANCERS
Author(s)
Gupta J1, Sehgal M2
1PAREXEL International, New Delhi, India, 2PAREXEL International, Chandigarh, India
Presentation Documents
OBJECTIVES: To assess the association between antidepressants (ADs) use and male-only cancers. METHODS: Embase and PubMed were searched for relevant human studies published in English. Data was extracted for study population, study characteristics, interventions, and risk of male cancers (prostate [PC], testicular [TC], penile [PNC], and male breast cancer [MBC]). RESULTS: Of the 374 results that were obtained from the literature search, five case-control studies (three assessed PC risk and two assessed TC risk) and one case-report (assessed MBC risk) met the inclusion criteria. None of the included studies assessed PNC risk. In a population-based study, no significant association was found between selective serotonin reuptake inhibitors (SSRIs) use and PC (risk ratio [RR]=1.01 [95% CI: 0.82-1.25]). Similarly, no significant association was found between ADs use and PC risk in other two studies. Significantly positive association was found between tricyclic antidepressants (TCAs) use for 2-5 years and PC with a RR of 1.31 (1.14-1.51), 1.58 (1.29-1.93), and 2.42 (1.87-3.12) for the low, medium, and high average daily dose levels, respectively. However, authors acknowledged detection bias as possible reason for the observed association. SSRIs were found to be significantly associated with TC (fluoxetine RR=2.51 [1.39-4.53]; paroxetine RR=2.44 [1.25-4.74]) in one study. A four-year follow-up study re-tested the association with 12 ADs. In multivariate analyses in this study, neither fluoxetine (odds ratio [OR]=1.22 [0.88-1.71]) nor paroxetine (OR=1.19 [0.78-1.83]) or all SSRIs combined (OR=1.21 [0.92-1.58]) were significantly associated with TC risk. All TCAs (OR=1.06 [0.75-1.51]) and all ADs combined (OR=1.06 [0.85-1.32]) were also not associated with TC risk. In a report of three cases, authors reported an anecdotal association between SSRIs and MBC. CONCLUSIONS: The results do not indicate significant association between ADs use and risk of male-only cancers. In most cases, weak positive associations disappeared after adjusting for confounding factors.
Conference/Value in Health Info
2015-11, ISPOR Europe 2015, Milan, Italy
Value in Health, Vol. 18, No. 7 (November 2015)
Code
PCN7
Topic
Epidemiology & Public Health
Topic Subcategory
Safety & Pharmacoepidemiology
Disease
Mental Health, Oncology