OBJECTIVES: This study was aimed to describe the Health Related Quality of Life profile of Type 2 Diabetes Mellitus population attending outpatient clinics in Pakistan. METHODS: The study was designed as a cross-sectional descriptive survey. Type 2 diabetic patients attending a tertiary care institute in Sargodha, Pakistan were targeted for the study. The EuroQol EQ-5D was used for the assessment of Health Related quality of Life and was scored using values derived from the UK general population survey. Descriptive statistics were used for the elaboration of socio-demographic characteristics. The chi-square test was used to depict the possible association between study variables and Health Related Quality of Life. Where significant associations were noted, Phi and Cramer’s V constant were used for data interpretation accordingly. P < 0.05 was taken as significant. RESULTS: Three hundred and ninety two patients were approached for the study. The cohort was dominated by males (n=222, 56.60 %) with 5.58±4.09 years of history of Type 2 Diabetes Mellitus. The study highlighted poor Health related Quality of Life among patients with Type 2 Diabetes Mellitus (0.471 ± 0.336). Gender, marital status, education, monthly income, occupation, location and duration of the disease was reported to be significantly associated with Health Related Quality of Life (P<0.001).  CONCLUSIONS: Type 2 Diabetes Mellitus imposes a negative effect on health related quality of life. Attention is needed to highlight determinants of health related quality of life and to implement policies for better management of Type 2 Diabetes Mellitus, particularly in early treatment phases where improving Health Related Quality of Life is still possible.