Author(s)
Pashos CL1, Flowers CR2, Weiss M3, Lamanna N4, Farber C5, Kipps TJ6, Lerner S7, Kay N8, Sharman J9, Grinblatt DL10, Flinn IW11, Kozloff MF12, Swern AS13, Khan Z13, Street TK13, Sullivan KA13, Harding G14, Keating MJ71United BioSource Corporation, Lexington, MA, USA, 2Emory University, Atlanta , GA, USA, 3Thomas Jefferson University, Philadelphia, PA, USA, 4Memorial Sloan-Kettering Cancer Center, New York, NY, USA, 5Hematology Oncology Northern New Jersey, Morristown, NJ, USA, 6Moores Cancer Center, University of California - San Diego, La Jolla, CA, USA, 7MD Anderson Cancer Center, Houston, TX, USA, 8Mayo Clinic - Rochester, Rochester, MN, USA, 9US Oncology, Springfield, OR, USA, 10NorthShore University Health System, Evanston, IL, USA, 11Sarah Cannon Research Institute, Nashville, TN, USA, 12Ingalls Cancer Research Center, Harvey , IL, USA, 13Celgene Corporation, Summit, NJ, USA, 14United BioSource Corporation, Bethesda, MD, USA
OBJECTIVES: Among patients with chronic lymphocytic leukemia (CLL), advanced age is typically associated with limited functional status. We examined the relationship between age and health-related quality of life (HRQOL) for CLL patients treated in the United States (US). METHODS: Data were collected in Connect® CLL, a prospective US observational registry begun in 2010. Patient demographics and clinical characteristics were provided by clinicians. Patient HRQOL was self-reported in the clinic at enrollment. Patients completed the Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu), EQ-5D, and Brief Fatigue Inventory (BFI). FACT-Leu, EQ-5D and BFI scores were analyzed by age group (<65, 65-74, >74). Statistical significance of differences was ascertained by ANOVA (SAS 9.1). RESULTS: Baseline HRQOL data were reported by 899 patients from 161 centers. Patients were predominantly male (63%) and white (90%) with mean age at 69 (standard deviation 11) years. FACT-Leu results suggest that overall HRQOL is better among the 65-74 cohort than either younger or older patients (p=0.0421), reflecting better physical (p=0.0100) and CLL-specific (p=0.0083) scores. FACT-G scores are similar among the two older groups and better than the younger patients (p=0.0275), reflecting better emotional well-being (p=0.0127). EQ-5D data indicate that mobility is most impaired in the oldest group compared to the younger groups (p<0.0001), and that usual activities (p=0.0009) and pain/discomfort (p<0.0001) are worse in both younger and older cohorts compared to those 65-74. No significant differences were observed in fatigue measured by the BFI, or in overall HRQOL measured by the EQ-5D Visual Analogue Scale. CONCLUSIONS: Connect® CLL registry results indicate that overall HRQOL is not worse with older age, as both younger and older age groups have worse HRQOL in certain domains. Future analyses should determine how HRQOL is affected over time with treatment and changes in disease. These results serve as a baseline reference.
Conference/Value in Health Info
2012-06, ISPOR 2012, Washington, D.C., USA
Value in Health, Vol. 15, No. 4 (June 2012)
Code
PCN103
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Oncology
