OBJECTIVES: Hospital admissions are frequent for Crohn´s Disease (CD) patients, either to treat a flare-up or to have surgery. There are few data about CD in Latin America. Some studies, however, have pointed to an increase in the prevalence across the years. The aim of current the study is to analyze trends of the hospital admission rate by CD in three Latin American countries: Brazil, Chile and Mexico.     METHODS: Data from the years 2001  to 2008 on primary diagnosis of Crohn´s Disease were taken from Databases of Hospital Admission in Public Health System: DATASUS in Brazil, DEIS in Chile and SINAIS in Mexico. Numbers of hospital admission by country, year and age range were collected and weighted by age specific country population.  Trends in hospital admission rates over time were analyzed by Poisson general estimation equations with an autoregressive correlation matrix. Estimated coefficients were considered significant when p<0.05. RESULTS: In all countries the rate increased with the age. Mexico had the lower rates, which remain nearly constant over the years (0.09/100,000 inhabitants, p= NS).  In Chile, the rate has increased over the years (ß=0.45; annual risk ratio: 1.568 p<0.001), different from Brazil that showed a decrease (ß=-0111; annual risk ratio=0.893; p<0.001).  CONCLUSIONS: Reports from reference centers showed an increase in the number of cases in the three countries; however in Mexico the number of patients still very low. Therefore, the trend of hospital admission rates in Chile and Mexico seem to be similar as the reported disease frequency. Regarding Brazil, a possible explanation for the decrease in hospital admission could be changes in treatment practices, the financing of biological therapies in Public Health System since 2002. The trends of hospital admission vary across the Latin America countries, and national assistance programs for CD seem to have an impact on hospital admission rate.