OBJECTIVES: To determine the loss of work productivity and activity impairment (WPAI) due to non-compliant cost cutting in a diagnosed Atrial Fibrillation (AF) population. METHODS: The study consisted of data from the 2011 US National Health and Wellness Survey (NHWS), a web-based survey of 75,000 patients’ demographics, health care attitudes and health outcomes. Non-compliant cost cutting strategies were defined as taking less medication than prescribed, cutting tablets in half, buying fewer tablets, not filling prescriptions because of costs, not filling prescriptions and using over-the-counter medications instead, or buying prescriptions less often. Compliant strategies were defined as asking for generic alternatives, asking for samples, buying prescriptions multiple months at a time through mail order, using coupons, and using a discount card. Generalized linear regression models were used to determine the burden of engaging in non-compliant strategies on WPAI, controlling for demographics, health history, insurance status, and comorbidities. RESULTS: Out of 1,046 diagnosed AF patients taking a prescription medication for AF, 19.8% reported using non-compliant cost cutting strategies, 41.3% reported using compliant strategies only, and 38.9% reported not using any cost cutting strategies.  After controlling for demographics, health history, and comorbid conditions, among the employed respondents, non-compliant patients reported greater presenteeism (28.4%) and overall work productivity loss (29.9%) compared with patients who practice only compliant cost cutting strategies (11.8% vs. 12.8%, respectively, p<0.03 for both) . Non-compliant patients reported significantly more activity impairment (45.4% vs. 37.5%, p<0.003) before adjustments, but after adjustments, no differences were found. CONCLUSIONS: In AF patients, participating in non-compliant cost cutting strategies was found to be associated with greater presenteeism and overall work productivity loss. These patients should be identified and guided to improve compliance to their prescription medications to help avoid impairment while working.