OBJECTIVES: To describe the sex and sex communication experiences of females in second cycle institutions METHODS: A cross sectional study involving the use of structured questionnaire and interview guide was conducted with female students in two selected secondary-level institutions in Bekwai, Ghana. Data was collected from 391 randomly selected and consented female adolescent students aged 18 years or less in 2011. Data was analysed into descriptive statistics with statistical significance set at 0.05 or less and at 95% confidence interval RESULTS: The study revealed that 202/391(51.7) respondents had ever had sex, 134/202(66%) were currently having sex. Of 202 who had ever had sex, 151/202 (74.8%) discussed sex with their friends while 96/189(50.8%) who had never had sex also discussed sex with their friends. The top three major sources of sexual information was obtained from friends, 187/391(47.8%), parents 85/391(21.7%) and teachers, 70/391(17.9%). A majority, 55.5%, as compared to 41.9% of the respondents, disagreed that parents talk freely about sex. There were statistically significant associations between sex discussant and ever had sex (chi square = 271; p<0.01) and source of information on sex and ever had sex (chi square = 21.7; p = 0.01). CONCLUSIONS: A majority of female adolescent students are sexually active. Parents of female adolescents are unpopular sources of information about sex and hardly do they discuss sexual issues with adolescents. Understanding factors influencing parents’ willingness in discussing sexual issues about sex could be helpful in minimizing sex related problems among female adolescent students.