SATISFACTION WITH AND PREFERENCE FOR GOLIMUMAB AND ITS AUTO-INJECTOR AMONG RHEUMATOID ARTHRITIS PATIENTS SWITCHED FROM ADALIMUMAB OR ETANERCEPT
Author(s)
Tandon N1, Bolce R2, Naim A1, Bolge S1, Ellis L1, Piech CT1, Decktor D21Janssen Scientific Affairs, LLC, Horsham, PA, USA, 2Janssen Services, LLC, Horsham, PA, USA
Presentation Documents
OBJECTIVES: To evaluate patient satisfaction with golimumab (GLM) and its auto-injector in rheumatoid arthritis (RA) patients switched from adalimumab (ADA) or etanercept (ETA) due to inadequate disease control. METHODS: Data were from an interim analysis of 200 patients enrolled in GO-SAVE, a GLM multicenter, assessor-blinded, switch study of patients with active RA. Patients receiving methotrexate and having an inadequate response to current treatment with ADA or ETA entered the screening period at week -6 and continued current treatment. After re-screening at week 0, all eligible patients were actively switched to open-label GLM 50mg subcutaneous injections. Satisfaction prior to switching was assessed at week -2 for ADA or week -1 for ETA. Satisfaction with and preference for GLM were assessed at week 8. RESULTS: Mean (SD) age was 55.9 (11.3) years; 81.5% were female. Mean (SD) disease duration was 9.8 (9.7) years. Prior to switch, patients were treated with ADA pen (25.5%), ADA prefilled syringe (21.5%), ETA pen (27%), ETA prefilled syringe (24%), and ETA vial and syringe (2.0%). All 200 patients completed assessment at week -2 (ADA) or -1 (ETA); 170 completed the assessment at week 8 (GLM). At week 8, 82.9% were satisfied with the overall GLM experience, 80.0% were satisfied with injection frequency, and 75.3% were satisfied with injection device. Most patients experienced lower levels of injection related burning (80.0%), stinging (75.3%), discomfort (62.4%), redness (58.8%), and pain (57.6%) with the GLM auto-injector than with the previous injection device. Patients expressed greater preference for GLM over their previous medication (74.0%) and greater preference for the auto-injector (70.6%) over their previous injection device. CONCLUSIONS: A majority of RA patients switched to GLM from ADA or ETA were satisfied with their overall GLM experience, including preference for GLM and the auto-injector over previous medication and injection device.
Conference/Value in Health Info
2012-06, ISPOR 2012, Washington, D.C., USA
Value in Health, Vol. 15, No. 4 (June 2012)
Code
PMS66
Topic
Patient-Centered Research
Topic Subcategory
Stated Preference & Patient Satisfaction
Disease
Musculoskeletal Disorders