OBJECTIVES: Even though the lowest of the prices amongst reference countries are taken into account during reference piricing, these price are still relativley high according to our country's purchasing power. The price of a certain medication is considered normal in a developed country whereas that price for the same product presents itself higher than the purchasing power of developing country.Development of a new reference pricing system estimated in accordance with Turkey's GDPC is proposed. METHODS: The most essential requirement for reference pricing is to reach a new reference price based on the molecule significance coefficient(MSC) - obtained through an assessment and GDPC no higher than the lowest reference country price. A committe of 5 academicians convened from different universities has evaluated bevacizumab, erlotinib and rituximab, using the assessment form prepared on grounds of 5 questions for the calculation of the coefficient. New public pricesof the products were calculated by the use of the MSC. The pharmaceutical product pricing calculation is suggested as below: Product Price = ∑  ( Country GDPC/Ref. Country GDPC x Ref. Country Price) x Molecule Significance Coefficient; Mol. Sig. Coeff. =  Average Score/Total Score x 3. RESULTS: The MSC values for bevacizumab, erlotinib and rituximab were 1.09, 1.21 and 1.29, respectively. The probable the new calculated public prices depending the formulas were decreased from the public price, 37%, 40% and 21%, respectively. CONCLUSIONS: GDPC-based reference pricing sample may provide a new perspective in pharmaeutical pricing control in countries like Turkey. On the other hand, this can also provide an opinion for countries with insufficient facilities for approaching MSC and HTA, during reimbursement decision making. For instance, an MSC value under 1 is not included in reimbursement whereas one falling in between 2 and 3 is suggested for reimbursement.This can be similarly used for determining the MSC reimbursement levels independent from reference pricing.