OBJECTIVES: To describe quality of life (QoL) of college students in Venezuela and to explore the association between quality of life and perceived social support. METHODS: One hundred thirty-six students from the Colleges of Pharmacy and Architecture of  Central University of Venezuela were surveyed using a questionnaire that included  Spanish versions of  EQ-5D descriptive system, EQ visual analogue scale (EQ-VAS),   SF 36, and Interpersonal Support Evaluation List. The associations among QoL and social support measures were estimated computing Pearson's correlation coefficients. RESULTS: The sample consisted of 76 pharmacy students and 60 architecture students. The mean age was 20.01 years. Ninety-three students (68.9%) were females. Concerning the EQ-5D, fewer students reported some problems with mobility (8.8%,) and self-care ( 5.9%). Thirty-six students (26.5%) reported some problems with usual activity. Students reported more problems with pain (41.9%) and anxiety (37.5% reported some problems and  4.4% reported extreme problems).  Mean rate of own health on EQ-VAS was 76.75 (SD 16.42). Concerning the SF 36 dimensions, students scored higher in health concepts closely related with physical health (Physical Function = 93.18 (SD 9.4); Bodily Pain= 74.01 (SD 21.7) and scored lower in role-emotional (53.73, SD = 40.0) and vitality (56.07, SD = 20.8). Social support measures showed that the sample as a whole perceived themselves to be relatively well-supported with means (SD) of 80.21 (13.37) for appraisal, 78.90 (11.03) for emotional, 78.17(13.90) for tangible. All social support measures were significantly positively correlated with the EQ-VAS and with all the SF-36 scales.  CONCLUSIONS: Although, the cross-sectional design of the study does not allow us to draw conclusions regarding the direction of the relationships or causality, this exploratory study demonstrates that all dimensions of QoL are associated to perceive social support. Psychosocial support may offer one way to improve the quality of life of young populations.