OBJECTIVES: Modifiable risk factors in the US workforce have been documented previously, but knowledge of behavioral risk factor prevalence among working adults remains incomplete. To assess current national estimates for smoking, heavier alcohol consumption, obesity, insufficient exercise and fair/poor health status for working adults aged 20 years and older. METHODS: Analysis of nationally representative data collected from employed adults 20 years and older participating in the National Health Interview Survey (NHIS) 2010 (aged 20 to 64 years, n = 13,844, aged 20 to 39 years, n=6,495, aged 40 to 64 years, n=7,349, men aged 20 to 64 years = 6,825, women aged 20 to 64 years = 7,019). RESULTS: The prevalence of current smoking among working adults aged 20 to 64 years is 19.6%; younger workers (aged 20 to 39 years) have a significantly higher prevalence of current smoking than workers 40 to 64 years, (21.2% vs. 18.3%, p=0.001) and employed men have a significantly higher smoking prevalence than employed women (21.4% vs. 17.6%, respectively, p=<0.0001).  An estimated 5.7% and 5.5% of working men and women, respectively, report heavier alcohol consumption (p=0.5573, >2 drinks/day for men, >1 drink/day for women).  The prevalence of insufficient exercise is equivalent among working men and women, 30.6% and 31.0%, respectively. Obesity prevalence in the workforce is 33.5%; obesity rates are 31.6% and 35.1% among workers 20 to 39 years and 40 to 64 years, respectively (p=0.2665). Employed women and men are equally likely to report that their health is fair/poor (6.0% vs. 5.1%). CONCLUSIONS: Current smoking, insufficient exercise and obesity are prevalent in the US workforce. Effective workplace approaches including increased dissemination of educational information are needed to reduce the burden of these risk factors.