OBJECTIVES: To evaluate health care resource utilization (HRU) and health-related quality of life (HRQOL) between United Kingdom (UK) Neurogenic Detrusor Overactivity (NDO) patients with and without adequate response to anticholinergics. METHODS: A retrospective database analysis was conducted using the Adelphi OAB Disease Specific Programme, a multi-national, cross-sectional survey reported from both patients’ and physicians’ perspectives. The population for this analysis was limited to UK NDO patients with OAB with or without incontinence, excluding those with stress incontinence. Inadequate response to anticholinergics was defined by switching anticholinergics due to lack of efficacy or tolerability. HRU indicators included: 1) paid employment; 2) OAB-related hospitalization in the past 12 months; 3) ever having undergone OAB-related surgery; and 4) number of physician visits due to their bladder condition in the past three months. HRQOL was measured by the Incontinence Quality of Life Questionnaire (I-QOL) total score. Statistical differences were tested using Fisher’s exact test for dichotomous outcomes and Wilcoxon rank-sum test for continuous outcomes. RESULTS: The UK sample of patients with OAB or urinary incontinence was 1304 patients recruited by 122 physicians. A total of 40 NDO patients who filled out a self-completion questionnaire were identified, of whom 24 (60%) had inadequate response to anticholinergics.  A significantly higher proportion of patients with inadequate response to anticholinergics underwent OAB-related surgeries (N(%): 11(46%) vs. 0(0%), p<0.01) versus patients with adequate response. In addition, patients with inadequate response had significantly more physician visits (mean(SD): 3.6(2.7) vs. 1.7(1.6), p=0.03) and a statistically and clinically lower I-QOL total score (mean(SD): 49(18) vs. 72(23), p<0.01). The proportion of patients on paid employment or have had OAB-related hospitalization did not significantly differ between the groups. CONCLUSIONS: Patients with inadequate response to anticholinergics were more likely to have greater health resource utilization and lower quality of life compared with patients with adequate response.