OBJECTIVES: To examine patient insights and perspectives among individuals with psoriasis using novel multi-discriminate analysis (MDA). METHODS: Patient focus groups and online surveys were conducted from a nationally representative psoriasis patient panel from 2Q-4Q2010. Participants were asked about treatments, impact on daily life, accessibility and affordability, and knowledge about psoriasis. Key audio excerpts from focus group transcripts were used for moment-to-moment analysis in an online survey of psoriasis patients ≥18 years old. Cluster analysis was used to segment patients into mutually exclusive patient groups based patient characteristics and preferences. MDA was performed to identify key points of divergence in perspective/opinion on the focus group dialogue.   RESULTS: Of the 1013 respondents, 50% were female, 32% (n=321) had mild and 68% (n=692) had moderate-to-severe psoriasis. Patient ages in years were distributed as follows: 30% < 40; 45% 40-59 and 25% > 60. Patient preference for biologic treatments for psoriasis were as follows: 13% were currently taking a biologic, 42% would consider taking a biologic, 17% had previously taken a biologic, and 24% would not consider taking a biologic. Hierarchical and non-hierarchical cluster analyses were applied to the moment-to-moment affect traces that identified four unique patient clusters (# 1-4). MDA was used to identify the five most impactful time periods within the focus group audio segments. Cluster composition profiles were identified based upon demographic information and patient responses to behavioral and attitudinal questions.  CONCLUSIONS: Understanding complex patient perspectives on coping with disease is essential for delivering appropriate treatments over the lifelong course of psoriasis. This novel methodology begins to bridge this knowledge gap in understanding the patient-centered view of psoriasis. Furthermore, it improves the likelihood of recommending treatments in alignment with the patient’s needs to improve health-related quality-of-life, productivity, and well-being.