OBJECTIVES: To compare rates of Complementary and Alternative Medicine (CAM) use among individuals with and without disabilities.  METHODS: We used a cross-sectional design.  Our data source was the 2007 National Health Interview Survey files and the Adult Complementary and Alternative Medicine Supplement.  Individuals who reported limitation in activities due to any condition were considered having disability. Any use of CAM use in the past 12 months was derived from the adult CAM supplement and based on 21 different types of self or practitioner-based therapies. Our final study sample (N = 23,175) consisted of adult respondents over age 18 and who did not have any missing values for disability status or CAM.  Chi-square tests were performed to test significant group differences between disability status and any CAM use.  Logistic regression was used to assess the association between disability status and CAM use after controlling for demographic, socio-economic, access to care, health status, and life-style risk factors.  All analyses adjusted for the complex survey design.  RESULTS: Overall, 32% of the sample respondents reported CAM use in the past 12 months. Nearly one-third (31%) reported activity limitations.  The rates of CAM use was significantly higher among individuals with disability (38.9%) compared to those without disability (30.4%). Results from logistic regression suggested that people with a disability were almost 2 times as  likely to use CAM even after adjusting for other characteristics(AOR= 1.96, 95% CI= 1.75-2.18, p≤0.001).  CONCLUSIONS: Individuals with disabilities were more likely to use CAM use compared to individuals without disabilities. A plausible reason for greater use of CAM among individuals with disability could be due to the failure of conventional therapies in treatment and alleviation of symptoms.  Future studies need to examine as to whether greater CAM use among those with disability is related to failure of treatment with conventional therapies.