OBJECTIVES: This study aimed to explore the impact of smoking on productivity in Chronic Obstructive Pulmonary Disease (COPD). METHODS: Data from the National Health and Wellness Survey (NHWS) were used for this study. Respondents aged 40+ reporting diagnoses with COPD, chronic bronchitis, or emphysema in the US in 2009 or 2010 were included, using 2010 data for individuals completing the survey in both years. The smoking group included subjects diagnosed with COPD who reported currently smoking (n=1685). The former smoker group consisted of those diagnosed with COPD who reported not smoking in the last 11+ years (n=1932). The Work Productivity and Activity Impairment scale (WPAI) assessed productivity, including absenteeism, presenteeism, and overall work and non-work activity impairment. Multivariate generalized linear models were used to predict productivity impairment, with a negative binomial distribution and a log-link function. Covariates included age, sex, race, insurance status, marital status, income, BMI, alcohol use, exercise, and asthma diagnosis. Indirect costs were calculated using the U.S. Department of Labor’s 2009 Bureau of Labor Statistics average wages, adjusted for gender and age. These were multiplied by productivity impairment and then annualized to project yearly costs associated with lost productivity. RESULTS: Multivariable results for productivity data estimated the following differences between current smokers with COPD and former smokers with COPD: absenteeism (3% vs. 1%, p=.355), presenteeism (23% vs. 18%, p=0.010), overall work impairment (25% vs. 21%, p=0.043) and activity impairment (52% vs. 49%, p=0.004). Calculated mean indirect costs were estimated to be $10,905 versus $7,819 (p=0.002), or incremental mean indirect costs of $3,096 per year for current smokers. CONCLUSIONS: Compared with former smokers quitting 10+ years prior, COPD sufferers currently smoking have similar absenteeism, greater presenteeism, and mildly impaired overall work and activity impairment. Estimated incremental costs of productivity decreases are $3096 per year for current smokers with COPD.