OBJECTIVES: Currently in Brazil’s public healthcare, patients with psoriasis who fail the available treatment options (phototherapy, methotrexate, acitretin and cyclosporin) due to any cause, are experiencing a medical unmet need. This study is aimed to assess comorbidity, quality of life (QoL), work/productivity loss (WPL), and medical resource utilization in patients diagnosed with psoriasis (PdwP) in Brazil. METHODS: A total of 12,000 individuals’ (age 18+) self-reported data were collected from 2011 National Health and Wellness Survey (NHWS) in Brazil, a cross-sectional representative sample of the adult population. QoL was measured by the physical component score (PCS) and mental component score (MCS) of the Short Form-12 (SF-12). WPL was measured by the validated Work Productivity and Activity Impairment instrument. Medical resource utilization was measured by health care provider utilization, emergency room visits and hospitalization in the past 6 months. RESULTS: Of the 12,000 respondents, 205 (1.3%) were patients diagnosed with psoriasis (PdwP) (53.0% women). Mean age was 40.2. Higher percentage of co-morbidities was found among PdwP compared to patients not diagnosed with psoriasis (PndP): headache (71% vs. 54%), sleep difficulties (50% vs.24%), anxiety (50% vs.33%), insomnia (46% vs.22%), pain (42% vs.23%), skin allergies (40% vs.17%), migraine (40%vs.20%), Heartburn (38% vs.23%) hay fever (37% vs.15%), nasal allergies (33% vs.21%), depression (33% vs.16%), rhinitis (32%vs.11%), high blood pressure (29% vs.16%), gingivitis (22%vs.6%), nail fungus (20%vs.7% ), dry eye (20% vs.5%), anemia (19% vs.6%), diabetes type 1 or 2 (19% vs.4%). PdwP had a lower mean PCS (45.8 vs. 49.7) and MCS (42.3 vs.47.0), more visiting health practitioners (87.0% vs.76.0%), emergency room visits (36.0%vs.22.0%), and hospitalizations for a medical condition (21.0% vs.10.0%) over the past 6 months compared to the PndP group. Furthermore, PdwP reported higher presenteeism (30.4% vs.14.8%), work productivity loss (34.0% vs 18.9%) and activity impairment (36.5% vs.20.9%) compared to the PndP group. All mentioned differences were statistically significant at p<0.05. CONCLUSIONS: From Brazilian NHWS results, PdwP suffer from impairment in QoL, WPL, and more co-morbidities.