OBJECTIVES: About 121 million people worldwide suffer from depression, and it is the fourth leading cause of disability, according to the World Health Organization. Cross-cultural studies have revealed that depressive disorders constitute a public health problem in most societies. This study is aimed to assess co-morbidity, quality of life (QOL), work/productivity loss, and medical resource utilization in patients diagnosed with depression in Brazil. METHODS: A total of 12,000 Individuals’ (age 18+) self-reported data were collected from 2011 National Health and Wellness Survey (NHWS) in Brazil.. QOL was measured by the physical component score (PCS) and mental component score (MCS) of the Short Form-12 (SF-12). Loss of work/productivity was measured by the validated Work Productivity and Activity Impairment instrument. Medical resource utilization was measured by healthcare provider, emergency room visits and hospitalization in the past 6 months. RESULTS: Of the 12,000 respondents, 1,379 (10.8%) had been diagnosed with depression, predominantly women (67.5%). Highest proportion of depression diagnosed patients was found between those 18-34 years old (40.8%). Those diagnosed with depression reported more co-morbidities (anxiety 77.0%, headache 74.8%, sleep difficulties 59.1%, insomnia 56.65%, pain 47.2%, migraine 39.6%), lower mean scores of PCS (46.1 vs. 50.1) and MCS (35.8 vs. 48.3), more emergency room visits (42.4% vs. 19.3%), and more patients being hospitalized for any medical condition (19.7% vs. 8.6%) over the past 6 months compared to not diagnosed with depression group. Furthermore, patients diagnosed with depression reported greater overall work impairment (36.9% vs. 17.3%) and impairment in daily activity (44.5% vs. 18.3%) compared to patients not diagnosed with depression. All comparisons were statistically significant at p<0.05. CONCLUSIONS: Results from the Brazil NHWSindicate patients diagnosed with depression suffer from impairment in QOL, work/productivity loss, greater usage of health care resources and more co-morbidities. Findings indicate there is an unmet medical need in depressive patients in Brazil.