OBJECTIVES: Alzheimer’s disease (AD) is the most common type of dementia for which there is no cure. In a world where lifespan is increasing, dementia is becoming more evident. In 2010, approximately 35.6 million people were living with dementia and this number is likely to increase to 115.4 million in 2050. This study is aimed to assess co-morbidity, quality of life (QOL), work/productivity loss, and medical resource utilization in caregivers of AD in Brazil. METHODS: A total of 12,000 individuals’ (age 18+) self-reported data were collected from 2011 National Health and Wellness Survey (NHWS) in Brazil.. QOL was measured by the physical component score (PCS) and mental component score (MCS) of the Short Form-12 (SF-12). Loss of work/productivity was measured by the validated Work Productivity and Activity Impairment instrument. Medical resource utilization was measured by health care provider, emergency room visits and hospitalization in the past 6 months. RESULTS: Of the 12,000 respondents, 215 (1.6%) were identified as AD patient’s caregivers where 63.7% were women. The age group with the highest proportion of caregivers was 45-54yrs old (36.2%), and they are significantly older than non-caregivers (44.7 vs. 40.8, p<0.05). AD caregivers group reported more specific co-morbidities (insomnia 33.8%, cardiac arrhythmia 20.7%), similar mean scores of PCS (49.8 vs. 49.7) and MCS (47.3 vs. 46.9), similar percentage of emergency room visits (21.5% vs. 21.8%), and similar percentage of hospitalization visits (9.9 vs. 9.8) over the past 6 months compared to the group of not caregivers of AD patients. Furthermore, caregivers of AD patients’ group reported 22.3% impairment in daily activity compared to 22.1% in the group of not caregivers of AD patients. CONCLUSIONS: From the Brazil NHWS results, AD caregivers suffer from impairment in QOL, work/productivity loss and more specific co-morbidities. Findings indicate there is still an unmet medical need in AD caregivers in Brazil.