OBJECTIVES: Isotretinoin, medicine used to treat severe acne has been the subject of various studies to investigate the relationship between therapy and psychiatric disorders. At the same time, the demand has been growing this item in the National Health System (SUS) which incorporated the drug since 2001 and its use is standardized by the Clinical Protocol and Therapeutic Guidelines by SUS. The aim of work was to quantitatively evaluate the demand Isotretinoin of in the year 2011 and the financial impact of this item in the total distributed in Component Specialized Pharmaceutical Services –CEAF (program for access to medicines under SUS) METHODS: Survey demand data and distributed financial value of Isotretinoin 20 mg of 2011 in SIGAF-(Computerized Management of the State Pharmaceutical Assistance Minas Gerais) in relation to the total amount distributed to all items of CEAF.RESULTS: In 2011, the demand of the Isotretinoin was 9374 new patients, the second-placed; iron hydroxide 100 mg, 3111, budesonide + formoterol 400/200 mcg   was placed third with 2177. The total amount distributed was equivalent to 8715 million dollars, 8% of total expended with 196 medicines that make up the CEAF. CONCLUSIONS: Isotretinoin was the most requested in 2011 in CEAF, three times higher than the second and 4 times higher than the third. At the same time, spending on this medicine is relevant, considering the percentage of the total spent on all CEAF’s medications. This represents 11.6% of the total amount spent in the State of Minas Gerais with the treatment of cardiovascular diseases, chronic diseases most prevalent in Brazil according to WHO. Considering the known risks and the lack of conclusive studies on other adverse effects of Isotretinoin, the results highlight the need for closer monitoring of patients and control this medicine, in order to avoid the rampant consumption and irrational.